The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappaB) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ.
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Sayed et al. (2007) studied this question.
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