Diet and risk of dementia: Does fat matter? The Rotterdam Study

To the Editor: The recent article on risks associated with dietary fats for AD and vascular dementia by Engelhart et al.1 is interesting but as indicated in the article, at odds with several recent articles. The question is why? The ecologic study looked at entire populations.2 It was found that diet 4 years before the prevalence data had the highest correlation with AD. Dietary fat was the highest individual risk factor, but including fish in a multiple linear regression improved the correlation. Total energy supply …