In vivo molecular analysis examines oxidative protein folding in Leishmania tarentolae, highlighting evolutionary divergence in protist mitochondrial pathways lacking Mia40.
The discovery of the redox proteins Mia40/CHCHD4 and Erv1/ALR, as well as the elucidation of their relevance for oxidative protein folding in the mitochondrial intermembrane space of yeast and mammals, founded a new research topic in redox biology and mitochondrial protein import. The lack of Mia40/CHCHD4 in protist lineages raises fundamental and controversial questions regarding the conservation and evolution of this essential pathway.
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Turra et al. (2021) studied this question.
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