Key result
Duchenne muscular dystrophy is linked to higher myocardial native T1 and ECV versus healthy controls.
Why the study?
Can CMR T1 and ECV mapping detect diffuse extracellular matrix expansion in DMD patients with normal LVEF and without LGE compared to healthy controls?
Observational (n=42)
No
Can CMR T1 and ECV mapping detect diffuse extracellular matrix expansion in DMD patients with normal LVEF and without LGE compared to healthy controls?
Absolute Event Rate: 1045% vs 988%
p-value: p=0.001
CMR T1 and ECV mapping can detect early, diffuse myocardial extracellular matrix expansion in DMD patients before the onset of LVEF decline or LGE, suggesting their potential as surrogate endpoints in clinical trials.
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May identify early myocardial changes in DMD with preserved LVEF; leaves open validation as surrogate endpoints in trials.
Soslow et al. (2016) conducted an observational in Duchenne muscular dystrophy cardiomyopathy (n=42). Duchenne muscular dystrophy vs. Healthy controls was evaluated on Mean native T1 (p=0.001). Duchenne muscular dystrophy patients had significantly higher mean myocardial native T1 (1045 ms vs 988 ms) and extracellular volume fraction (0.31 vs 0.24) compared to healthy controls.
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