Key result
New unified mouse genetic resource helps decode lipid homeostasis and lipoprotein transport.
May advance mouse models of dyslipidemia; leaves open human translation and clinical relevance.
Lipoproteins are particles that transport fats (lipids) through the bloodstream. They differ in size and density based on the amount of lipids and proteins they carry. They are broadly broken down into several categories: Chylomicrons, which are the largest and least dense lipoproteins transport dietary triglycerides and cholesterol from the intestines to the liver and other tissues. Very-low-density lipoproteins (VLDL) are larger particles that carry triglycerides synthesized in the liver to tissues.
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Viesi et al. (2024) studied Lipid homeostasis. A unified mouse genetic resource is presented to decode the complexities of lipid homeostasis and lipoprotein transport.
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