Key result
Increasing age in DMD is linked to a ~2.5% annual decline in echocardiographic image quality.
Why the study?
Does echocardiographic image quality deteriorate with increasing age in children and young adults with Duchenne muscular dystrophy?
Observational (n=13)
No
Does echocardiographic image quality deteriorate with increasing age in children and young adults with Duchenne muscular dystrophy?
Effect estimate: regression coefficient -2.49 (95% CI -4.73, -0.25)
p-value: p=0.032
Echocardiographic image quality significantly deteriorates with increasing age in patients with Duchenne muscular dystrophy, suggesting that alternative imaging modalities like CMR should be considered by mid-adolescence.
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Echo quality decline with age in DMD may limit reliable LV assessment; leaves open optimal CMR transition timing in surveillance.
Power et al. (2017) conducted an observational in Duchenne muscular dystrophy (n=13). Increasing patient age was evaluated on Endocardial border delineation percentage (EBDP) score (regression coefficient -2.49, 95% CI -4.73, -0.25, p=0.032). Echocardiographic image quality significantly deteriorates with increasing age in patients with Duchenne muscular dystrophy, with the endocardial border delineation score decreasing by 2.5% for each 1-year increase in age.
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