Summary: The bacteriostatic effect of specific antiserum on Clostridium welchii type A was profoundly influenced by the pH and Eh of the medium. With suitable concentrations of specific antiserum relatively high pH and Eh values led to a well-marked inhibition of growth accompanied by destruction of the bacteria. A relatively low pH or Eh led to a decrease or abolition of the inhibitory power of the specific antiserum. Neither complement nor properdin appeared to be involved in the bacteriostatic effect.
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Bullen et al. (1964) studied this question.