Abstract —The molecular parameters of tryptophan hydroxylase (EC 1.14.16.4) from rat midbrain and murine mast cell were determined by gel filtration and sucrose density gradient ultracentrifugation. The enzyme from rat midbrain has a calculated molecular weight of 220, 000, a Stokes radius of 55.6 Å, a frictional ratio of 1.28, and a sedimentation coefficient of 9.63 S. The mast cell enzyme has a calculated molecular weight of 144, 000, a Stokes radius of 50.3 Å, a frictional ratio of 1.35, and a sedimentation coefficient of 6.97 S. It appears that the tryptophan hydroxylase species from rat midbrain and murine mast cell represent distinct molecular entities.
No takes yet. Share an insight, caveat, or question.
Kuhn et al. (1979) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: