Key result
Reduced quinolinic acid after bariatric surgery is linked to improved fasting glucose and HbA1c.
Why the study?
Does bariatric surgery alter kynurenine metabolite concentrations and are these changes associated with improved glucose homeostasis in women with obesity?
Population
91 women with obesity (44 normoglycemic and 47 diabetic)
Comparison
Bariatric surgery vs Baseline (pre-surgery)
Design
Cohort
Follow-up
1 year
Authors
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Quinolinic acid reduction may mediate glycemic benefits after bariatric surgery; hypothesis-generating and requires prospective trials before clinical consideration.
Cohort (n=91)
No
Does bariatric surgery alter kynurenine metabolite concentrations and are these changes associated with improved glucose homeostasis in women with obesity?
Effect estimate: β = -1.311
p-value: p=0.019
Bariatric surgery induces a global down-regulation of kynurenine metabolites, and specific changes in quinolinic and xanthurenic acids are associated with improvements in glucose homeostasis.
Favennec et al. (2016) conducted a cohort in Severe obesity (n=91). Bariatric surgery vs. Baseline (pre-surgery) was evaluated on Association between one-year change in quinolinic acid concentrations and change in fasting glucose (β = -1.311, p=0.019). One year after bariatric surgery, the reduction in quinolinic acid concentrations was significantly associated with improvements in fasting glucose (p=0.019) and HbA1c (p=0.014).
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