Key result
Fick principle guides ECMO management by quantifying oxygen delivery, recirculation, and transpulmonary blood flow.
This review provides a physiological framework based on the Fick principle for managing oxygen delivery and blood flow in patients receiving veno-arterial or veno-venous ECMO.
Extracorporeal membrane oxygenation (ECMO) can be delivered in veno-arterial (VA) and veno-venous (VV) configurations based on the cannulation strategy. VA and VV ECMO are delivered primarily for haemodynamic and respiratory support in patients with severe heart and lung failure, respectively. The Fick principle describes the relationship between blood flow and oxygen consumption - key parameters in the physiological management of extracorporeal support. This review will discuss the application of the Fick principle in: (i) recirculation in VV ECMO; (ii) the quantification of oxygen delivery (DO2) in VV ECMO and (iii) the quantification of transpulmonary blood flow and systemic arterial oxygen saturation in VA ECMO.
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Hoong Sern Lim (2021) conducted a review in Severe heart and lung failure. Extracorporeal membrane oxygenation (ECMO) was evaluated. The Fick principle is a key physiological concept for managing extracorporeal membrane oxygenation, guiding the quantification of oxygen delivery, recirculation, and transpulmonary blood flow.
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