We have found that shochu distillery by-product (SDBP) contains a growth promoting factor that can be extracted with ether. In the present study, we administered hexane-extracts of SDBP (HSDBP) to broiler chickens and observed changes in skeletal muscle protein degradation in order to clarify the mechanism of growth promotion due to SDBP feeding. The pectoralis superficial muscle weight was significantly increased by HSDBP feeding. Plasma N(tau)-methylhistidine concentration was significantly decreased by HSDBP, showing that the rate of muscle protein degradation decreased. It was also found that the expression of mRNA of ubiquitin-proteasome system and calpain was decreased by HSDBP. These results indicate that growth promotion due to SDBP is caused by suppression of skeletal muscle protein degradation, which is related to the ubiquitin-ptoteasome system and calpain.
No takes yet. Share an insight, caveat, or question.
Kamizono et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: