Various α-substituted propargylamines, prepared in three steps from (R)-phenylglycinol, are readily isomerized at 0 °C with KAPA to form terminal acetylenic amines, without any detectable epimerization of the chiral center, as already observed for propargyl alcohols. Enantiomerically pure primary α-substituted alkynylamines can be easily obtained in two steps after removal of the ferrocenylmethyl protective group and oxidative cleavage of the chiral appendage. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
No takes yet. Share an insight, caveat, or question.
Blanchet et al. (2002) studied this question.