Key result
Preserved acetylcholinesterase fibers despite absent sympathetic skin responses suggest primary demyelination in autonomic neuropathy.
Population
14 patients (12 with chronic neuropathy, 2 with acute autonomic sensory and motor neuropathy)
Design
Case_series
Authors
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May aid prognostic categorization of acute autonomic neuropathies by demyelinating versus axonal type; leaves open prospective validation before clinical use.
Case Report (n=14)
Dysautonomia with acute idiopathic neuropathy can be categorized into postganglionic axonopathic (poor recovery) and preganglionic demyelinating (better recovery) types.
Takanori Yokota (1994) conducted a case report in Dysautonomia with acute sensory motor neuropathy (n=14). Acute sensory motor neuropathy vs. Chronic neuropathy was evaluated on Acetylcholinesterase-positive fiber density and sympathetic skin response. In patients with acute autonomic sensory and motor neuropathy, acetylcholinesterase-positive fiber density was preserved despite absent sympathetic skin responses, indicating primary demyelination.
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