Photoinduced Copper-Catalyzed Radical Aminocarbonylation of Cycloketone Oxime Esters

A visible light-induced and exogenous photosensitizer-free, copper-catalyzed radical aminocarbonylation of cycloketone oxime esters with CO gas and amines is developed. The mild catalytic system involving CuCl and N, N, N -tridentate ligand shows good reactivity and chemoselectivity, and tolerates a wide range of cycloketone oxime esters and alkyl/aryl amines, giving the corresponding cyanoalkylated amides in moderate to good yields. Preliminary mechanistic studies suggest that the reaction involves a Cu I /Cu II /Cu III -based catalytic cycle and radical intermediate.