Key result
Identical voltage-sensing sodium channel mutations yield differential functional effects relevant to cardiovascular disorders.
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Demonstrates how identical mutations in the voltage sensing domain of sodium channels can produce different functional effects, which is relevant for understanding cardiovascular disorders.
Elhanafy et al. used Molecular Dynamics simulations and electrophysiology to show how identical mutations in the volgage sending domain of sodium channels can yield differential functional effects.
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Christian Jorgensen (2025) studied this question. Identical mutations in the voltage-sensing domain of sodium channels can yield differential functional effects relevant to cardiovascular disorders.
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