Key result
Rare neuroendocrine laryngeal tumors demonstrate highly aggressive behavior, metastatic potential, and poor clinical outcomes.
Case Report (n=4)
No
Neuroendocrine laryngeal tumors are rare but highly aggressive neoplasms with a poor prognosis.
May signal greater lethality in laryngeal paraganglioma than recognized; leaves open optimal management for these rare neuroendocrine tumors.
BACKGROUND: Neuroendocrine tumors are rare neoplasms arising from neural and epithelial origin. METHODS AND RESULTS: The case records of 4 patients with the diagnosis of neuroendocrine laryngeal tumor were retrospectively reviewed. In this analysis of our medical records, we describe a series of 4 men with neuroendocrine laryngeal tumors treated in our department since 1994, including the first extremely aggressive and lethal laryngeal paraganglioma reported in the English-language literature. We also discuss the classification, the macro and microscopical characteristics, clinical and pathologic findings, and treatment of these neoplasms. CONCLUSION: Although neuroendocrine laryngeal tumors account for approximately 1% of all neoplasms in the larynx, its majority represents very aggressive tumors showing a capacity for metastasis and portending poor outcome.
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Angouridakis et al. (2012) conducted a case report in Neuroendocrine laryngeal tumor (n=4). Neuroendocrine laryngeal tumors was evaluated on Clinical and pathologic findings, and treatment outcomes. Neuroendocrine laryngeal tumors are rare but mostly very aggressive neoplasms with a capacity for metastasis and poor outcomes, as observed in a series of 4 men.
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