Key result
Nonpharmacologic treatment alone is linked to fewer syncope relapses versus combined pharmacologic therapy.
Why the study?
Recurrences are common in neurally mediated syncope, motivating an evaluation of the effectiveness of nonpharmacologic treatments alone in preventing syncope relapse.
Do nonpharmacological treatments alone prevent syncope relapse in patients aged 5-20 years with neurally mediated syncope?
Cohort (n=70)
Do nonpharmacological treatments alone prevent syncope relapse in patients aged 5-20 years with neurally mediated syncope?
p-value: p=<0.001
Nonpharmacologic treatment alone may be effective in preventing syncope relapses in pediatric and young adult patients with neurally mediated syncope.
May support nonpharmacologic therapy alone in pediatric neurally mediated syncope; leaves open incremental benefit of pharmacotherapy in randomized trials.
BACKGROUND: Recurrences are common in neurally mediated syncope. The aim of this study is the evaluation of the effectiveness of nonpharmacologic treatments alone in preventing of syncope relapse. METHODS: 70 patients (age 5-20 years) with neurally mediated syncope were enrolled. Thirty patients received pharmacologic therapies along with nonpharmacological methods, and 40 patients received just nonpharmacological treatments then followed them for 36 months. The incidences of different outcomes were analyzed with descriptive statistics using percentages. RESULTS: < 0.001). CONCLUSIONS: Nonpharmacologic treatment is very effective in the prevention of syncope relapses and can be a substitute for pharmacologic drugs in the initiation of treatment and if done correctly.
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Dehghan et al. (2019) conducted a cohort in neurally mediated syncope (n=70). Nonpharmacological treatments alone vs. Pharmacologic therapies along with nonpharmacological methods was evaluated on syncope relapse (p=<0.001). Nonpharmacologic treatment alone was effective in preventing syncope relapses compared to combined pharmacologic and nonpharmacologic therapy (P<0.001).
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