Key result
IGF-I gene disruption in mice reduces GH signals, while IGF-I treatment increases body weight.
Population
Homozygous (IgfI-/-), heterozygous (IgfI+/-), and wild-type (IgfI+/+) fetal and adult mice
Comparison
IGF-I treatment for 2 weeks vs Untreated mice and wild-type (IgfI+/+) mice
Design
Preclinical
Follow-up
2 weeks
Authors
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Rodent data link IGF-I to somatotroph size and lactotroph stimulation without differentiation effects; leaves open human pituitary relevance.
IGF-I plays no role in differentiation of pituitary cells, affects the size of somatotrophs in females, and is a stimulator of lactotrophs in both genders.
Ştefăneanu et al. (1999) studied Disrupted Insulin-Like Growth Factor I Gene. IGF-I gene disruption and IGF-I treatment vs. Wild-type (IgfI+/+) mice was evaluated on Pituitary morphology (somatotroph and lactotroph changes). IGF-I gene disruption in mice decreased GH RNA signal in fetuses and diminished GH cell size in adult females, while IGF-I treatment increased body weights and decreased GH hybridization signal.
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