Key result
SR 25989 reduces pulmonary metastatic foci by ~33% and inhibits microvessel development in mice.
Why the study?
Does SR 25989 inhibit angiogenesis and metastatic dissemination in a murine melanoma model?
Population
In vitro rat aorta fragment embedded in a fibrin gel; in vivo C57BL/6 mice inoculated in the foot pad with…
Comparison
SR 25989 vs Control mice
Design
Preclinical
Follow-up
Until time of sacrifice
Authors
Loading...
May support preclinical anti-angiogenic research in melanoma; leaves open translation to human therapy.
Does SR 25989 inhibit angiogenesis and metastatic dissemination in a murine melanoma model?
Effect estimate: 33% reduction
SR 25989 demonstrates potent anti-angiogenic properties capable of inhibiting metastatic dissemination and growth in a murine model, despite lacking anti-aggregant activity.
Mah-Becherel et al. (2002) studied Pulmonary metastasis. SR 25989 vs. Normal saline was evaluated on Number of macroscopic pulmonary metastatic foci (33% reduction). SR 25989 reduced the average number of macroscopic pulmonary metastatic foci by 33% in treated mice and inhibited spontaneous microvessel development in vitro.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: