Key result
GCKR rs780094 polymorphism shows no association with NAFLD.
Why the study?
The GCK rs780094 polymorphism has been associated with obesity, type II diabetes, and dyslipidemia, conditions highly related to NAFLD etiology, but its relationship with NAFLD required evaluation in this population.
Is the GCK rs780094 polymorphism associated with non-alcoholic fatty liver disease in patients from Tabriz city?
Case-Control (n=146)
No
Is the GCK rs780094 polymorphism associated with non-alcoholic fatty liver disease in patients from Tabriz city?
p-value: p=>0.05
The GCK rs780094 polymorphism does not appear to be associated with non-alcoholic fatty liver disease in this Iranian population.
No association in this Iranian cohort; leaves open GCKR rs780094 role in NAFLD across populations.
OBJECTIVE: GCK rs780094 polymorphism is a single nucleotide polymorphism that has been associated with obesity, type II diabetes and dyslipidemia in some populations, conditions that highly related to NAFL etiology. The present study aimed to evaluate the relationship between NAFLD and rs780094 polymorphism in patients with NAFLD in Tabriz city, northwest of Iran. The rs780094 polymorphism was determined in 74 patients with NAFLD by PCR-RFLP technique. Demographic information was collected using a questionnaire and biochemical analysis was performed using standard laboratory methods. RESULTS: There was a significant difference between case and control subjects for alanine aminotransferase, aspartate aminotransferase, HDL-C and triglycerides (P < 0.05). Analysis by PCR-RFLP method revealed that there were no significant differences between NAFLD and healthy subjects for rs780094 polymorphism in the study population. The results of this study indicated that rs780094 polymorphism is not associated with NAFLD in subjects from Tabriz city.
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Mohammadi et al. (2020) conducted a case-control in Non-alcoholic fatty liver disease (NAFLD) (n=146). GCKR rs780094 polymorphism vs. Healthy subjects without NAFLD was evaluated on Association of GCKR rs780094 polymorphism with NAFLD (p=>0.05). The GCKR rs780094 polymorphism was not significantly associated with non-alcoholic fatty liver disease in the studied Iranian population.
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