The kinetic parameters of choline accumulation by synaptosomes prepared from different regions of guinea‐pig brain (cortex, brainstem, and cerebellum) were determined. Choline was accumulated by a high affinity transport process for all regions tested and the apparent Michaelis constants were similar. However, the apparent maximal velocities of choline accumulation for the brain regions differed; the differences were related to the amount of acetylcholine formed by the respective regions. The results suggested that the maximal velocity of the high affinity transport process may reflect the density of cholinergic nerve endings within brain regions.
No takes yet. Share an insight, caveat, or question.
Carroll et al. (1975) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: