Key result
NAFLD is not linked to higher pre-diabetes or diabetes rates among overweight and obese adults.
Why the study?
To determine the prevalence of diabetes mellitus and pre-diabetes among patients with NAFLD having BMI ≥ 25 kg/m2 compared to controls without fatty liver with the same BMI.
Is the prevalence of pre-diabetes and diabetes mellitus higher in overweight/obese patients with NAFLD compared to those without NAFLD?
Cross-Sectional (n=302)
No
Is the prevalence of pre-diabetes and diabetes mellitus higher in overweight/obese patients with NAFLD compared to those without NAFLD?
Absolute Event Rate: 82.08% vs 82.51%
Pre-diabetes and diabetes mellitus are highly prevalent in overweight/obese individuals regardless of the presence of NAFLD.
High prevalence of pre-diabetes and diabetes in overweight/obese adults irrespective of NAFLD; leaves open independent contribution and supports broad screening.
Objectives: To determine the prevalence of diabetes mellitus and pre-diabetes among patients with NAFLD having BMI ≥ 25 kg/m2and compare it with the control group with non-fatty liver with same BMI. Study Design: Prospective, Analytical and Cross-sectional study. Setting: Department of Medicine, Civil Hospital Karachi. Period: January 2015 to October 2016. Material & Methods: The study was conducted among two groups of patients, one with non-alcoholic fatty liver disease (NAFLD), having BMI of ≥25kg/m2and they were compared with a control group having BMI≥25kg/m2 but without fatty liver on ultrasound. Result: Out of 201 NAFLD participants, 82.08% had pre-diabetes and diabetes mellitus, while 82.51% of participants from non-NAFLD (n=101) had pre-diabetes or diabetes mellitus. Insulin resistance was more common among non-NAFLD group than NAFLD group. Most of the metabolic parameter analysed in the study among two groups having slight difference, and they were statistically significant. Conclusion: Pre-diabetes and diabetes mellitus is a frequently reported problem among NAFLD and overweight/obese patients. Insulin resistance was found to be a significant predictor of diabetes mellitus.
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Jabeen et al. (2020) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) and overweight/obesity (n=302). Non-alcoholic fatty liver disease (NAFLD) vs. Non-fatty liver with BMI ≥ 25 kg/m2 was evaluated on Prevalence of pre-diabetes and diabetes mellitus. Among overweight and obese adults, the frequency of pre-diabetes and diabetes mellitus was similarly high in both those with NAFLD (82.08%) and without NAFLD (82.51%).
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