Direct Mechano‐Catalytic Synthesis of Amides Using Brass Balls via Cross‐Coupling of Isocyanides With Arylboronic Acids or in Situ Generated N‐Aryl‐Pyridinium Salts

Given the importance of amides as valuable biological molecules and pharmaceutics, there is a surge of synthetic methods to access amides adopting the solvent‐free synthetic routes. Herein, we report an alternative approach for the mechanochemical synthesis of N‐alkyl/aryl amides via brass balls catalyzed cross‐coupling between isocyanides and anilines or arylboronic acids mediated by pyridinium tetrafluoroborate (Pyry‐BF 4 ) or TEMPO. Adopting a wide range of substrate scope, the present protocol offers a straightforward synthetic access to N‐alkyl/aryl amides in good to excellent yields in short reaction times.