Binding of Aminoglycoside Antibiotics to the Duplex Form of the HIV‐1 Genomic RNA Dimerization Initiation Site

Targeting HIV RNA: High-resolution X-ray structures of the HIV-1 genomic RNA dimerization initiation site (DIS) extended duplex bound to several aminoglycoside antibiotics have been obtained (see ribostamycin complex as an example). They show the feasibility of targeting viral RNA with small drugs, and open up the possibility of structure-based rational drug design aimed against viral replication.