A new simple and rapid quantitative proton magnetic resonance method has been developed for the determination of piroxicam in pure form and in pharmaceutical dosage forms. Among other peaks, the PMR spectrum of piroxicam has a well defined sharp singlet (at ≃ 3.00 p.p.m.) which is chosen for quantitative measurements. The method involves comparing the integral of this signal to that of a sharp singlet of maleic acid (6.3 p.p.m.) which is used as internal standard. The proposed procedure gives accurate and reproducible results when applied for the analysis of authentic drug, its tablets and capsules. In addition, the PMR spectrum obtained helps in confirming the identity and purity of the drug.
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Fattah et al. (1988) studied this question.
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