Key result
NSAIDs, glucocorticoids, antineoplastics, immunosuppressants, and antidepressants are linked to drug-induced arterial hypertension.
Why the study?
Some drugs can lead to the development of drug-induced arterial hypertension, motivating an effort to systematize and analyze data on causative drugs, epidemiology, mechanisms, risk factors, diagnosis, and treatment.
Which drugs are associated with the development of drug-induced hypertension and how should it be diagnosed and managed?
Which drugs are associated with the development of drug-induced hypertension and how should it be diagnosed and managed?
Drug-induced hypertension is a common, often unrecognized adverse reaction requiring careful pharmacological anamnesis in patients with uncontrolled or rapidly increasing blood pressure.
Alerts clinicians to monitor BP with implicated agents; leaves open prospective validation of incidence and prevention.
Some drugs can lead to the development of drug-induced arterial hypertension. The aim of the work is to systematize and analyze the data about drugs that can cause the development of drug-induced hypertension, as well as on epidemiology, pathophysiological mechanisms, risk factors, clinical picture, diagnosis and differential diagnosis, treatment and prevention of drug-induced hypertension. As a result of data analysis, it was revealed that drugs: glucocorticosteroids, antineoplastic drugs, immunosuppressants, nonsteroidal anti-inflammatory drugs, antidepressants and some others are associated with the development of hypertension. The mechanisms of development of drug-induced arterial hypertension are not fully established and require further study. Drug-induced arterial hypertension is still one of the most common and often unrecognized adverse reactions. The clinical manifestations of drug-induced hypertension are not specific. The symptoms are associated with target organ damage or complications of hypertension and may include a headache, nausea, dizziness, blurred vision, anxiety, shortness of breath, etc. patients with previously well-controlled hypertension or cases of uncontrolled hypertension. Therefore, it is always necessary to pay attention to the patient’s history, pharmacological anamnesis, rapid increases in blood pressure in patients with previously well-controlled hypertension, or cases of uncontrolled hypertension.
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Остроумова et al. (2022) conducted a review in Drug-induced arterial hypertension. Various drugs (glucocorticosteroids, antineoplastic drugs, immunosuppressants, NSAIDs, antidepressants) was evaluated. Various drugs, including glucocorticosteroids, antineoplastic drugs, immunosuppressants, NSAIDs, and antidepressants, are associated with the development of drug-induced arterial hypertension.
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