A method is proposed to control degradation rates of biodegradable polyester matrices for DDS and medical implantable materials. The degradation rates of poly(lactic acid), poly β-hydroxybutyrate and β-hydroxybutyrate-valerate copolymer matrices, which have poor degradability, could be accelerated by incorporating basic compounds, such as cinnarizine and clonidine, as a hydrolysis accelerator. The rates could be controlled by changing the loading amount and the basicity of the basic compounds.
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Kishida et al. (1989) studied this question.
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