Key result
Rat aortic valves exhibit extracellular collagen turnover exceeding 8 weeks alongside faster intracellular protein renewal.
Why the study?
The long-term behaviour of the aortic-valve allograft appears dependent on the maintenance of its matrix.
Distinct turnover rates in rat aortic valves warrant caution assuming rapid matrix remodeling; leaves open human disease relevance.
The long-term behaviour of the aortic-valve allograft seems to be dependent on the maintenance of its matrix. Protein and collagen synthesis was studied in rat aortic-valves. Quantitative and qualitative methods proved the production of at least two protein pools. One protein pool is localised intracellularily with a 'turn-over' time of about 2 weeks, and a second pool is localised extracellularly with a 'turn-over' time of at least 8 weeks. The latter protein pool mainly consists of collagen.
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Kamp et al. (1979) studied Aortic-valve matrix maintenance. Protein and collagen synthesis assessment was evaluated on Protein and collagen synthesis and turn-over time. Protein and collagen synthesis in rat aortic valves revealed an intracellular protein pool with a 2-week turn-over and an extracellular collagen pool with a turn-over of at least 8 weeks.
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