What does this research mean for the field?

Synchronous primary malignancies of the anal canal (squamous cell carcinoma) and stomach (adenocarcinoma) can coexist and present as severe anemia, highlighting the need for thorough evaluation of patients with rectal bleeding. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Describe an exceptionally rare clinical case of synchronous anal canal squamous cell carcinoma and gastric adenocarcinoma presenting with severe anemia.

September 14, 2026Discover OncologyOpen Access

Synchronous carcinoma of the anal canal and stomach presenting as severe anemia: a case report

View Full Paper

Ask AI

Bookmark

Authors

MPManoj Narayan Pragasam DCDr Karikal Chakaravarthi TCTharun Ganapathy Chitrambalam

Discussion

Member takes

Overview

Case report demonstrates synchronous anal and gastric cancers in a 56-year-old female, highlighting the need for complete gastrointestinal evaluation in severe anemia.

Key Points

Describe an exceptionally rare clinical case of synchronous anal canal squamous cell carcinoma and gastric adenocarcinoma presenting with severe anemia.
Clinical, laboratory, endoscopic, and histopathological evaluation of a 56-year-old female presenting with rectal bleeding and severe pallor (N=1).
Disease staging using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT).
Laboratory testing identified profound anemia with a hemoglobin level of 5 g/dL.
Endoscopic biopsies confirmed synchronous gastric adenocarcinoma of the antrum and squamous cell carcinoma of the anal canal.
Staging revealed locally advanced anal disease with nodal involvement and metastatic gastric adenocarcinoma, prompting treatment with the systemic CAPOX chemotherapy regimen.

Cite This Study

Pragasam et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b2f70926e14a848b19da https://doi.org/10.1007/s12672-026-05812-5

View Full Paper

Ask AI

Bookmark

September 14, 2026Discover OncologyOpen Access

Synchronous carcinoma of the anal canal and stomach presenting as severe anemia: a case report

View Full Paper

Ask AI

Bookmark

Authors

MPManoj Narayan Pragasam DCDr Karikal Chakaravarthi TCTharun Ganapathy Chitrambalam

Discussion

Member takes

Overview

Case report demonstrates synchronous anal and gastric cancers in a 56-year-old female, highlighting the need for complete gastrointestinal evaluation in severe anemia.

Key Points

Describe an exceptionally rare clinical case of synchronous anal canal squamous cell carcinoma and gastric adenocarcinoma presenting with severe anemia.
Clinical, laboratory, endoscopic, and histopathological evaluation of a 56-year-old female presenting with rectal bleeding and severe pallor (N=1).
Disease staging using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT).
Laboratory testing identified profound anemia with a hemoglobin level of 5 g/dL.
Endoscopic biopsies confirmed synchronous gastric adenocarcinoma of the antrum and squamous cell carcinoma of the anal canal.
Staging revealed locally advanced anal disease with nodal involvement and metastatic gastric adenocarcinoma, prompting treatment with the systemic CAPOX chemotherapy regimen.

Cite This Study

Pragasam et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b2f70926e14a848b19da https://doi.org/10.1007/s12672-026-05812-5

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark