What does this research mean for the field?

Specific negatively correlated miRNA-mRNA pairs, such as IL6-hsa-miR-9-5p and FOXO1-hsa-miR-153-3p, modulate key oncogenic pathways including IL6/JAK-STAT, TGFβ signaling, and cellular senescence in pediatric T-cell acute lymphoblastic leukemia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify dysregulated microRNAs and their downstream target genes to elucidate altered oncogenic signaling networks in pediatric T-cell acute lymphoblastic leukemia.

September 14, 2026Discover OncologyOpen Access

Differential expression analysis of miRNAs and identification of potential key genes in pediatric T-cell acute lymphoblastic leukemia

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Authors

AJAaradhana Joshi PKParminder Kaur SKSargeet Kaur

Discussion

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Overview

Transcriptomic analysis uncovers dysregulated miRNA-mRNA networks in pediatric T-cell acute lymphoblastic leukemia, highlighting candidate biomarkers for targeted therapeutic intervention.

Key Points

To identify dysregulated microRNAs and their downstream target genes to elucidate altered oncogenic signaling networks in pediatric T-cell acute lymphoblastic leukemia.
Conducted integrative bioinformatic profiling across three public pediatric T-ALL miRNA sequencing datasets (E-MTAB-7446, E-MTAB-11987, and GSE89978).
Predicted target genes using TargetScan, miRDB, and miRTarBase, constructed interaction networks via Cytoscape, and correlated findings with institutional patient transcriptomic data.
Identified critical hub genes—including BCL2, CCND, PTEN, SIRT1, GSK3B, IL6, NFKB1, and SMAD4—with prominent roles in PI3K-Akt signaling and cellular senescence.
Demonstrated significant negative correlations in pairs such as IL6-hsa-miR-9-5p, FOXO1-hsa-miR-153-3p, and hsa-miR-296-3p-STAT5A, which drive aberrant IL6/JAK-STAT and TGF-β signaling.

Cite This Study

Joshi et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b32d0926e14a848b1f85 https://doi.org/10.1007/s12672-026-05868-3

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September 14, 2026Discover OncologyOpen Access

Differential expression analysis of miRNAs and identification of potential key genes in pediatric T-cell acute lymphoblastic leukemia

View Full Paper

Ask AI

Bookmark

Authors

AJAaradhana Joshi PKParminder Kaur SKSargeet Kaur

Discussion

Member takes

Overview

Transcriptomic analysis uncovers dysregulated miRNA-mRNA networks in pediatric T-cell acute lymphoblastic leukemia, highlighting candidate biomarkers for targeted therapeutic intervention.

Key Points

To identify dysregulated microRNAs and their downstream target genes to elucidate altered oncogenic signaling networks in pediatric T-cell acute lymphoblastic leukemia.
Conducted integrative bioinformatic profiling across three public pediatric T-ALL miRNA sequencing datasets (E-MTAB-7446, E-MTAB-11987, and GSE89978).
Predicted target genes using TargetScan, miRDB, and miRTarBase, constructed interaction networks via Cytoscape, and correlated findings with institutional patient transcriptomic data.
Identified critical hub genes—including BCL2, CCND, PTEN, SIRT1, GSK3B, IL6, NFKB1, and SMAD4—with prominent roles in PI3K-Akt signaling and cellular senescence.
Demonstrated significant negative correlations in pairs such as IL6-hsa-miR-9-5p, FOXO1-hsa-miR-153-3p, and hsa-miR-296-3p-STAT5A, which drive aberrant IL6/JAK-STAT and TGF-β signaling.

Cite This Study

Joshi et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b32d0926e14a848b1f85 https://doi.org/10.1007/s12672-026-05868-3

View Full Paper

Ask AI

Bookmark