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September 14, 2026Advanced Synthesis & CatalysisOpen Access

Unlocking the Potential of Organoaluminum Reagents for Versatile C─C Couplings Using YPhos‐Pd Catalysts

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Authors

NKNicolas KaiserJBJ. BusseBWBen Wichmann

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Overview

Experimental study demonstrates efficient cross-coupling of aryl chlorides with organoaluminum reagents using YPhos-palladium catalysts, highlighting broad utility for complex molecule synthesis.

Key Points

  • To establish a general and efficient palladium-catalyzed cross-coupling methodology between challenging aryl chlorides and diverse organoaluminum nucleophiles.
  • Utilized strongly donating ylide-functionalized phosphines (YPhos) complexed with palladium catalysts.
  • Tested cross-coupling across in situ generated alkyl-, aryl-, alkenyl-, and alkynylaluminum reagents with aryl chlorides under mild conditions, including at room temperature.
  • The YPhos-palladium system delivered high yields and selectivities across a broad scope of coupling partners.
  • The catalytic protocol exhibited robust functional group tolerance, enabling late-stage functionalization of complex molecular architectures.

Cite This Study

Kaiser et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3580926e14a848b22e2https://doi.org/10.1002/adsc.70757
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