Patient Out-of-Pocket Spending on Generic and Brand-Name Prescription Drugs

Christopher L. Cai; Aaron S. Kesselheim; Benjamin N. Rome

doi:10.1001/jamanetworkopen.2026.33401

September 11, 2026JAMA Network OpenOpen Access

Patient Out-of-Pocket Spending on Generic and Brand-Name Prescription Drugs

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Key Points

To characterize and evaluate annual patient out-of-pocket expenditures for generic versus brand-name prescription drugs in the United States.
Conducted a cross-sectional study examining annual patient out-of-pocket prescription drug costs in the US.
Assessed and categorized individual expenditure levels comparing generic medications against brand-name alternatives.
Delineated patient-level annual out-of-pocket financial obligations associated with generic prescription drug use.
Identified substantial differences in direct out-of-pocket spending burdens between brand-name medications and their generic equivalents.

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Implication

Cross-sectional study evaluates annual out-of-pocket spending on generic versus brand-name medications in US patients, highlighting drug cost disparities across prescription types.

Abstract

This cross-sectional study characterizes annual patient out-of-pocket spending on generic vs brand-name prescription drugs in the US.

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Cite This Study

Cai et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3770926e14a848b2613 https://doi.org/10.1001/jamanetworkopen.2026.33401

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Patient Out-of-Pocket Spending on Generic and Brand-Name Prescription Drugs

Key Points

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Implication

Abstract

Discussion

Cite This Study

Patient Out-of-Pocket Spending on Generic and Brand-Name Prescription Drugs

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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