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Multicenter retrospective study finds psychological factors correlate with symptom severity in burning mouth syndrome, highlighting the need for individualized clinical management.
OBJECTIVE: The aim of this study was to evaluate differences among patients with Burning Mouth Syndrome (BMS) in hematological parameters and clinical features, and to assess their associations with BMS symptoms. METHODS: This multicenter retrospective study included 348 patients from Brazil, Italy, Japan, and United States. Clinical and hematological characteristics were compared across populations ; logistic regression assessed associations with severe symptoms. CONCLUSION: BMS exhibits population-related variability in hematological and clinical profiles. Psychological factorsmay be associated with symptom severity, whereas hematological parameters were not, highlighting the importance of considering population-related characteristics in clinical management.
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Kimura et al. (2026) studied this question.
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