Animal study demonstrates coordinated behavioral and physiological changes during core temperature shifts in mice, indicating a reliable method to track internal thermal set-points.
neurons reduced Tc, along with coordinated cold-seeking behavior, reduced thermogenesis, and enhanced heat-loss responses, consistent with an inferred downward shift in the Tc set-point. Conversely, inhibition of these neurons induced warm-seeking behavior, enhanced thermogenesis, and heat-conservation responses, accompanied by elevated Tc, suggesting an inferred upward shift in the Tc set-point. Overall, this strategy provides a practical and reproducible approach for inferring Tc set-point dynamics in mice and will facilitate mechanistic studies of thermoregulation.
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Huang et al. (2026) studied this question.
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