Immune Toxicities After CAR-T and Bispecific T-Cell Engager Therapies

Q: What does this research mean for the field?

CAR-T and bispecific T-cell engager therapies are associated with specific immune toxicities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Julia G. Carter; Jonaphine Mata; T.A. Di Vitantonio; Rupali Sood; R. Scott Stephens; Kristina Montemayor

doi:10.1093/atsscholar/aapag058

September 12, 2026ATS ScholarOpen Access

Immune Toxicities After CAR-T and Bispecific T-Cell Engager Therapies

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Key Points

Characterize the biological mechanisms, clinical presentations, and management approaches for immune toxicities resulting from CAR-T and bispecific T-cell engager therapies.
Narrative clinical review synthesizing current evidence on immune-related adverse events associated with engineered cellular therapies and bispecific antibodies.
Identifies cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome as primary systemic toxicities driven by hyperactive T-cell activation.
Emphasizes prompt toxicity grading and intervention protocols, including cytokine-directed antagonists and corticosteroids, to control severe adverse responses.

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Implication

Clinical review details immune toxicities in cancer patients receiving CAR-T and bispecific T-cell engagers, highlighting essential diagnostic and management strategies.

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Cite This Study

Carter et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3df0926e14a848b31d7 https://doi.org/10.1093/atsscholar/aapag058

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Immune Toxicities After CAR-T and Bispecific T-Cell Engager Therapies

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Immune Toxicities After CAR-T and Bispecific T-Cell Engager Therapies

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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