Review details systematic brain MR spectroscopy protocols and metabolic profiles across neurologic disorders, highlighting improved diagnostic differentiation alongside standard MRI.
Key Points
To provide a structured, clinically actionable framework for brain magnetic resonance spectroscopy (MRS), covering acquisition protocols, spectral interpretation, and disease differentiation.
Reviewed technical acquisition parameters including voxel selection, magnetic field strength, echo time, and sequence choice.
Synthesized spectral biomarker profiles (such as N-acetylaspartate, choline, creatine, lactate, and myo-inositol) across neoplastic, infectious, demyelinating, and neurodegenerative conditions.
Determined that combining metabolic spectra with conventional MRI and clinical context resolves diagnostic ambiguity across overlapping neuropathologies where isolated metabolite shifts lack specificity.