Clonidine as an adjuvant to 0.25% bupivacaine and 0.25% levobupivacaine in supraclavicular brachial plexus block: Post-operative hemodynamics

Local anaesthetics are drugs that produce reversible conduction blockade of impulse along central and peripheral nerve pathways after regional anaesthesia. With progressive increases in concentrations of local anaesthetics, the transmission of autonomic, somatic sensory and somatic motor impulses are interrupted, producing autonomic nervous system blockade, sensory anaesthesia, and skeletal muscle paralysis in the area innervated by the affected nerve. A prospective, randomized, double blinded comparative clinical study was conducted in 80 patients of either sex requiring elective upper limb surgeries after obtaining an informed written consent. Statistical analysis of post-operative hemodynamic parameters included, Heart rate (HR), systolic (SBP) and diastolic blood pressures (DBP), Mean arterial pressures (MAP) and peripheral oxygen saturation (SpO2).