Key result
Female sex in schizophrenia spectrum disorder is associated with ~147% higher odds of chronic physical multimorbidities.
Why the study?
While the link between physical illnesses and schizophrenia spectrum disorder is well-established, the role of gender in chronic physical multimorbidities remains unclear.
Are there gender-based differences in the prevalence and early onset of chronic physical multimorbidities in patients with schizophrenia spectrum disorder compared to the general population?
Cross-Sectional (n=1,166)
Are there gender-based differences in the prevalence and early onset of chronic physical multimorbidities in patients with schizophrenia spectrum disorder compared to the general population?
Women with schizophrenia spectrum disorder face a disproportionately higher risk of early-onset chronic physical multimorbidities compared to men, highlighting the need for gender-tailored holistic care.
Women with schizophrenia spectrum disorder show higher multimorbidity odds than men; leaves open whether gender-specific screening improves outcomes.
AIM: The association between various physical illnesses and schizophrenia spectrum disorder (SSD) is well-established. However, the role of gender remains unclear. The present study explored the gender-based differences in the prevalence and early onset of chronic physical multimorbidities (CPM) in patients with SSD and the general population (GEP). METHODS: We recruited 329 SSD patients and 837 GEP controls in this nested cross-sectional study. The primary outcome was the prevalence of the chronic physical multimorbidities, especially in the youngest age group (<35 years). RESULTS: Women with SSD had more than double the odds for having CPM than men (OR = 2.47; 95% CI 1.35-4.50), while the gender-related burden of chronic diseases in controls was nearly the same (OR = 0.89; 95% CI 0.65-1.22). Furthermore, the prevalence of chronic disease in younger women patients was significantly higher than in controls (P = .002), while younger men did not seem to experience this increased comorbidity burden. CONCLUSIONS: This study suggests that women with SSD are at increased physical comorbidity risk compared to men, particularly early in the course of psychiatric illness. Tailored and individualized treatment plans must consider this, aiming to deliver holistic care and effective treatment outcomes.
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Filipčić et al. (2019) conducted a cross-sectional in Schizophrenia spectrum disorder (n=1,166). Female gender vs. Male gender was evaluated on Prevalence of chronic physical multimorbidities (OR 2.47, 95% CI 1.35-4.50). Women with schizophrenia spectrum disorder had more than double the odds of having chronic physical multimorbidities compared to men (OR 2.47; 95% CI 1.35-4.50).
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