A Pd(II)-catalyzed, selective δ-C(sp 3 )–H and δ-C(sp 2 )–H arylation method for free primary aliphatic amines using NH 2 as a native directing group has been developed. A variety of free primary amines with adjacent quaternary centers and/or with alpha esters react with a diverse range of aryl and heteroaryl iodides to provide δ-aryl and δ-heteroaryl amines.
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Lin et al. (2019) studied this question.
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