Key result
LV apex-to-base mechanical shortening delay parallels the direction of electric activation in porcine hearts.
Why the study?
Limited information exists regarding apex-to-base differences in the longitudinal and circumferential deformation sequence of the left ventricle and whether they parallel differences in depolarization and repolarization.
Population
8 porcine beating hearts in situ
Design
Experimental in situ animal study
Authors
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Links apex-base lengthening gradient to relaxation timing in animals; extends LV mechanics insights but leaves open human diastolic relevance.
Apex-to-base delay in mechanical shortening of the left ventricle parallels the electric activation sequence, with relaxation gradients potentially facilitating active restoration of the LV cavity in diastole.
Sengupta et al. (2005) studied this question. Measurement of electric activation and mechanical deformation was evaluated on Apex-to-base differences in electric activation and progression of longitudinal and circumferential shortening and lengthening sequences. In 8 porcine hearts, the apex-to-base delay in mechanical shortening of the left ventricle paralleled the apex-to-base direction of the electric activation sequence.