Anaphylaxis to propofol during cerebral aneurysm clipping

Anaphylaxis is a potentially life-threatening hypersensitivity reaction, most typically caused by neuromuscular blocking agents or antibiotics in the peri-operative setting. Propofol is the most common induction agent used during anaesthesia, and the occurrence of anaphylaxis is rare. This is a case report of suspected propofol anaphylaxis after induction of anaesthesia for cerebral aneurysm clipping surgery in a 51-year-old man who had previously been exposed to propofol. Recognition of the early signs of anaphylaxis, prompt management and follow-up allergy skin testing are crucial for confirming the diagnosis.