Key result
Malnutrition is linked to anthracycline-induced cardiomyopathy in children, proving fatal in 75% of patients.
Why the study?
Is malnutrition associated with an increased risk of anthracycline-induced cardiomyopathy in children?
Case-Control
Is malnutrition associated with an increased risk of anthracycline-induced cardiomyopathy in children?
Malnutrition may be a risk factor for the development of severe, often fatal, anthracycline-induced cardiomyopathy in children.
Malnutrition associated with resistant, fatal anthracycline cardiomyopathy in children; leaves open whether screening or repletion alters risk.
The nutritional status of children in whom cardiomyopathy resulted from anthracycline chemotherapy was compared to that of a matched control group of patients who were treated similarly but who had no evidence of cardiac toxicity. Those with cardiotoxic reactions were found to be more often malnourished than were their matched controls. Once clinical manifestations of cardiotoxocity developed, the course was relentless and resistant to treatment and ended in death in 75% of the patients.
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Obama et al. (1983) conducted a case-control in Anthracycline cardiomyopathy. Poor nutritional status vs. Matched controls without cardiac toxicity was evaluated on Malnutrition frequency. Children with anthracycline-induced cardiomyopathy were more often malnourished than matched controls, with clinical cardiotoxicity proving resistant to treatment and fatal in 75% of patients.
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