Supramolecular assembly: The ordered tetrahydrate of piperidine-2-carboxylic acid (see figure) is analysed using X-ray diffraction with topological analysis of the electron density distribution function. This highly accurate method probes both the cooperativity effects of H-bonding and the influence of solute on water molecule aggregation in these polyhydrates.
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Lyssenko et al. (2006) studied this question.
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