Key result
Progressive partial lipodystrophy is linked to elevated triglycerides and lipoproteins despite normal thyroid function.
Why the study?
The metabolic and endocrine characteristics of progressive partial lipodystrophy, including lipid levels, thyroid status, and glucose tolerance, were not fully characterized.
Observational (n=10)
Women with uncomplicated progressive partial lipodystrophy exhibit elevated plasma triglycerides and increased pre-beta lipoprotein and chylomicra, but normal cholesterol, thyroid function, and glucose tolerance.
Case links progressive partial lipodystrophy to hypertriglyceridemia; leaves open generalizability and need for prospective confirmation.
Eight women with uncomplicated progressive partial lipodystrophy and two with progressive lipodystrophy and diabetes mellitus were studied. Plasma triglyceride levels were significantly elevated in the subjects with uncomplicated lipodystrophy; serum cholesterol, phospholipid, and plasma free fatty acid levels were normal. Paper electrophoresis showed increases in serum pre-beta lipoprotein and chylomicra. Thyroid function, as measured by radioiodine and stable iodine studies, was normal. Some subjects had a raised basal metabolic rate. Intravenous glucose tolerance was normal in patients with the uncomplicated disease.
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Rifkind et al. (1967) conducted an observational in Progressive partial lipodystrophy (n=10). Progressive partial lipodystrophy was evaluated on Plasma triglyceride levels. Progressive partial lipodystrophy was associated with significantly elevated plasma triglyceride levels, increased serum pre-beta lipoprotein and chylomicra, but normal thyroid function.
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