Key result
Canine cardiac myxoma contains mesenchymal stem-like cells positive for Oct4 and ALDH1 pluripotency markers.
Why the study?
Cardiac myxoma is rare in dogs and its histogenic origin has not yet been established, though involvement of mesenchymal stem cells has been suggested in humans.
Case Report (n=1)
This is the first report identifying mesenchymal stem-like cells with an Oct4 and ALDH1-positive profile in a canine cardiac myxoma.
Hypothesis-generating for stem cell roles in canine myxoma; leaves open translational relevance to human cardiac tumors.
Cardiac myxoma is a rare disease in dogs. Its histogenic origin has not yet been established, but the involvement of mesenchymal stem cells has been suggested in humans. Here we report an encapsulated and benign cardiac myxoma located at the entrance to the pulmonary trunk of the heart of an 8-year-old male Yorkshire Terrier dog presenting sudden death in the absence of clinical symptoms related to cardiac alterations. Hematoxylin/eosin staining demonstrated the mixoid origin of the myxoma, showing abundant hypocellular stroma with polygonal cells, while immunohistochemistry (IHC) corroborated its mesenchymal lineage with the detection of vimentin and α-SMA positive cell populations. In addition, IHC showed some cell populations in the stroma to be immunoreactive to the pluripotency markers Oct4 and ALDH1. In conclusion, this is the first report of the presence of mesenchymal stem-like cells with an Oct4 and ALDH1-positive IHC profile in a canine cardiac myxoma.
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Alfaro et al. (2020) conducted a case report in Cardiac myxoma (n=1). Histological and immunohistochemical analysis was evaluated on Presence of mesenchymal stem-like cells. Immunohistochemical analysis of a canine cardiac myxoma revealed the presence of mesenchymal stem-like cells positive for Oct4 and ALDH1 pluripotency markers.
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