Key result
Updated UK guidelines harmonize pediatric DKA management with more permissive Holliday-Segar fluid rates.
Why the study?
Diabetic ketoacidosis is a life-threatening complication of type 1 diabetes mellitus requiring careful intervention to optimize glycaemic control and reduce mortality and devastating complications such as cerebral oedema.
This article reviews recent updates to UK fluid therapy guidelines for managing diabetic ketoacidosis in children and young people.
Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus. Careful and timely intervention is required to optimise glycaemic control and reduce the risk of mortality and devastating complications. Of these, cerebral oedema is the leading cause of death, with a mortality rate of approximately 25%. This article highlights the recent updates to UK fluid therapy guidelines for DKA and provides clinical context for the benefit of paediatricians and junior doctors in light of this new guidance.
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Rugg-Gunn et al. (2021) conducted a review in Diabetic ketoacidosis (DKA). Updated fluid therapy guidelines (BSPED and NICE 2020) vs. Previous guidelines (NICE 2015) was evaluated. Updates to the 2020 UK NICE and BSPED guidelines have harmonized the management of pediatric diabetic ketoacidosis, recommending a more permissive fluid rate using the Holliday-Segar formula.
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