Key result
Infant apparent life-threatening events linked to altered autonomic control and higher sleep HRV versus controls.
Why the study?
Decreased heart rate variability occurs in central hypoventilation and sudden infant death syndrome, but whether it is altered in infants with apparent life-threatening events was unknown.
Does heart rate variability differ in infants with apparent life-threatening events compared to healthy controls?
Case-Control (n=100)
Does heart rate variability differ in infants with apparent life-threatening events compared to healthy controls?
p-value: p=0.004
Infants with apparent life-threatening events exhibit altered heart rate variability patterns, suggesting underlying differences in autonomic control.
Altered HRV in ALTE infants supports autonomic involvement; leaves open predictive utility or intervention targets.
Heart rate variability (HRV) is often used as an index of sympatho-vagal balance. A decreased HRV has been observed in patients with central hypoventilation and in infants who have later succumbed to sudden infant death syndrome (SIDS). The aim of the present study was to investigate whether HRV is altered in infants with apparent life-threatening events (ALTE), a group with an increased risk of SIDS. Fifty infants with ALTE were compared with 50 age- and sex-matched controls. ECG was recorded overnight in all infants. Two sequences of RR intervals free of artefacts were selected from each sleep state and spectral analysis of RR variability was performed. The mean and SD of RR and the low (LFPow) and high (HFPow) frequency power were analysed. In active sleep (AS) the LF/HF ratio was lower in ALTE infants, but no differences were seen in either the LFPow or the HFPow. In quiet sleep (QS), however, ALTE infants had higher SD-RR (p= 0.006), greater HFPow (p= 0.02) and VLFPow (very low frequency power, p= 0.02) than the control infants. The same results were seen when the two sleep states were combined for analysis, ALTE infants had higher SD-RR (p= 0.004), HFPow (p= 0.006) and VLFPow (p= 0.04). Conclusion: The different HRV pattern in ALTE infants compared to healthy controls suggests an altered autonomic control.
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A. Edner (2000) conducted a case-control in Apparent life-threatening events (ALTE) (n=100). Apparent life-threatening events (ALTE) vs. Age- and sex-matched healthy controls was evaluated on Heart rate variability (SD-RR) during combined sleep states (p=0.004). Infants with apparent life-threatening events exhibited altered autonomic control, including higher SD-RR (p=0.004) and high-frequency power (p=0.006) during sleep, compared to healthy controls.
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