What does this research mean for the field?

An electrochemical three-component reaction of isonitriles, elemental sulfur, and diamines enables the efficient and regioselective synthesis of 1,2,5-thiadiazines under mild conditions. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Develop a green, mild, and efficient electrochemical three-component annulation strategy to synthesize biologically active 1,2,5-thiadiazines using elemental sulfur.

September 14, 2026Advanced Synthesis & Catalysis

Electrosynthesis of 1,2,5‐Thiadiazines via Three‐Component Annulation of Isocyanides, Elemental Sulfur, and Diamines

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Authors

ZQZhi-Gang Quan JJJun-Yi Jiang YPYing Peng

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Overview

Laboratory study demonstrates electrochemical synthesis of 1,2,5-thiadiazines from elemental sulfur and isonitriles, providing a mild, green route for drug-relevant heterocycle construction.

Key Points

Develop a green, mild, and efficient electrochemical three-component annulation strategy to synthesize biologically active 1,2,5-thiadiazines using elemental sulfur.
Conducted an electrochemical three-component reaction combining isonitriles, elemental sulfur, and diamines in a single pot at room temperature.
Tested reaction scope and functional group tolerance using a range of aliphatic and aryl isonitrile substrates.
Successfully synthesized a library of 1,2,5-thiadiazines with yields reaching up to 77%.
Achieved simultaneous, regioselective formation of one C─N bond, one C─S bond, and one S─N bond with high atom economy and functional group tolerance under mild conditions.

Cite This Study

Quan et al. (2026) studied this question.

synapsesocial.com/papers/6aa7dfc60926e14a848b3da2 https://doi.org/10.1002/adsc.70759

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September 14, 2026Advanced Synthesis & Catalysis

Electrosynthesis of 1,2,5‐Thiadiazines via Three‐Component Annulation of Isocyanides, Elemental Sulfur, and Diamines

View Full Paper

Ask AI

Bookmark

Authors

ZQZhi-Gang Quan JJJun-Yi Jiang YPYing Peng

Discussion

Member takes

Overview

Laboratory study demonstrates electrochemical synthesis of 1,2,5-thiadiazines from elemental sulfur and isonitriles, providing a mild, green route for drug-relevant heterocycle construction.

Key Points

Develop a green, mild, and efficient electrochemical three-component annulation strategy to synthesize biologically active 1,2,5-thiadiazines using elemental sulfur.
Conducted an electrochemical three-component reaction combining isonitriles, elemental sulfur, and diamines in a single pot at room temperature.
Tested reaction scope and functional group tolerance using a range of aliphatic and aryl isonitrile substrates.
Successfully synthesized a library of 1,2,5-thiadiazines with yields reaching up to 77%.
Achieved simultaneous, regioselective formation of one C─N bond, one C─S bond, and one S─N bond with high atom economy and functional group tolerance under mild conditions.

Cite This Study

Quan et al. (2026) studied this question.

synapsesocial.com/papers/6aa7dfc60926e14a848b3da2 https://doi.org/10.1002/adsc.70759

View Full Paper

Ask AI

Bookmark