What question did this study set out to answer?

To evaluate the antioxidant capacity of physiological folate forms and determine the specific chemical pharmacophore responsible for their protective activity.

November 27, 2003FEBS LettersOpen Access

Tetrahydrofolate and 5‐methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore

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Authors

BRBashir M. RezkTulane University GHGuido R.M.M. HaenenMaastricht University WVW. J. F. van der VijghInserm

Discussion

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Implication

Biochemical analysis uncovers potent antioxidant activity in reduced folates, suggesting an electron-donating pterin core mediates cellular protection.

Key Points

To evaluate the antioxidant capacity of physiological folate forms and determine the specific chemical pharmacophore responsible for their protective activity.
Measured peroxynitrite scavenging activity across various physiological forms of folate and structurally related derivatives.
Assayed the inhibition of lipid peroxidation by these folate compounds in vitro.
Tetrahydrofolate and 5-methyltetrahydrofolate exhibited the strongest antioxidant activity among physiological folates, with peroxynitrite scavenging potency exceeding lipid peroxidation inhibition.
The pterin core, specifically 4-hydroxy-2,5,6-triaminopyrimidine, was identified as the antioxidant pharmacophore, heavily driven by an electron-donating 5-amino group.

Cite This Study

Rezk et al. (2003) studied this question.

synapsesocial.com/papers/6aa7e75a5a44c3b67fae5ddf https://doi.org/10.1016/s0014-5793(03)01358-9

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November 27, 2003FEBS LettersOpen Access

Tetrahydrofolate and 5‐methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore

View Full Paper

Ask AI

Bookmark

Authors

BRBashir M. RezkTulane University GHGuido R.M.M. HaenenMaastricht University WVW. J. F. van der VijghInserm

Discussion

Member takes

Implication

Biochemical analysis uncovers potent antioxidant activity in reduced folates, suggesting an electron-donating pterin core mediates cellular protection.

Key Points

To evaluate the antioxidant capacity of physiological folate forms and determine the specific chemical pharmacophore responsible for their protective activity.
Measured peroxynitrite scavenging activity across various physiological forms of folate and structurally related derivatives.
Assayed the inhibition of lipid peroxidation by these folate compounds in vitro.
Tetrahydrofolate and 5-methyltetrahydrofolate exhibited the strongest antioxidant activity among physiological folates, with peroxynitrite scavenging potency exceeding lipid peroxidation inhibition.
The pterin core, specifically 4-hydroxy-2,5,6-triaminopyrimidine, was identified as the antioxidant pharmacophore, heavily driven by an electron-donating 5-amino group.

Cite This Study

Rezk et al. (2003) studied this question.

synapsesocial.com/papers/6aa7e75a5a44c3b67fae5ddf https://doi.org/10.1016/s0014-5793(03)01358-9

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