Key result
Elevated troponin in intracranial hemorrhage shows inconsistent outcome associations, lacking sufficient data for routine monitoring.
Why the study?
Does cardiac-specific troponin elevation predict clinical events and worse outcomes in patients with intracranial hemorrhage?
Systematic Review
Does cardiac-specific troponin elevation predict clinical events and worse outcomes in patients with intracranial hemorrhage?
Current evidence is insufficient to recommend routine cardiac-specific troponin monitoring for prognostic purposes in patients with intracranial hemorrhage.
Answers are grounded in this paper and cite their sources.
May inform ICH prognosis; leaves open whether troponin should guide care or requires prospective validation.
BACKGROUND: Cardiac-specific troponin (Tn) serum concentrations have proved to be important diagnostic and prognostic markers for acute myocardial infarction. Elevated levels in the setting of noncardiac diseases such as intracerebral hemorrhage also may provide useful prognostic information regarding outcome. METHODS: A systematic review of the English-language medical literature was performed using PubMed. Articles reporting original data were included. RESULTS: Ten reports qualified for review. A spectrum of cardiac abnormalities was observed in studied patients, sometimes more frequently in those with Tn elevations, whereas some had no such abnormalities, even if Tn was detected. Although some studies suggested a worse outcome in patients with elevated Tn levels, the findings were inconsistent. CONCLUSIONS: At this time, although the literature suggests an association between cardiac-specific Tn elevations and clinical events in patients with intracranial hemorrhage, data are insufficient to conclude that there is a consistent predictive value or to recommend routine Tn monitoring for prognosis.
No takes yet. Share an insight, caveat, or question.
Abdo et al. (2012) conducted a systematic review in Intracranial Hemorrhage. Elevated cardiac-specific troponin levels vs. Normal or undetected troponin levels was evaluated on Clinical events and outcome. Elevated cardiac-specific troponin levels in patients with intracranial hemorrhage showed inconsistent associations with worse clinical outcomes, lacking sufficient data for routine monitoring.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: